IMMI24 is a medical organization based in the Netherlands, dedicated to developing advanced immunotherapies and providing innovative healthcare solutions to patients worldwide.
Our mission is to inform, support, and empower patients while advancing the field of immune-based treatments — including next-generation macrophage activation therapies such as MAT-Pure, derived from the original GcMAF protein.
IMMI24 collaborates with clinics, physicians, and research institutions globally to conduct clinical studies, develop new formulations, and expand access to safe and effective immunotherapies.
Through science-driven innovation and an international network of medical professionals, we aim to deliver therapies that restore health, strengthen immunity, and improve quality of life.
GcMAF (Gc Protein-derived Macrophage Activating Factor) is a naturally occurring protein in the human body that plays a key role in the immune system’s defense mechanism.
Its primary function is to activate macrophages — specialized immune cells that detect and destroy cancer cells, viruses, and other harmful invaders.
MAT-Pure is built upon this natural principle, using a purified and enhanced GcMAF-based formulation to restore immune function and strengthen the body’s ability to protect and heal itself.
Macrophages (from the Greek “big eaters”) are powerful immune cells derived from monocytes, a type of white blood cell. They are vital components of both innate (non-specific) and adaptive (targeted) immunity.
Their primary role is to phagocytize — meaning to engulf and digest — pathogens, cellular debris, and cancer cells. Acting as both stationary guards and mobile defenders, macrophages continuously patrol the body to detect and neutralize harmful invaders.
Beyond direct defense, macrophages also stimulate other immune cells, such as lymphocytes, helping to coordinate the body’s broader immune response.
Through the activation of macrophages, MAT-Pure empowers the immune system to recognize and eliminate cancerous and infected cells, restoring the body’s natural ability to heal itself.
Macrophages are distributed throughout the entire body and are present in nearly every tissue, acting as the first line of immune defense. Their local forms adapt to the specific functions of each organ or environment.
| Body Area | Immune Cells Present |
|---|---|
| Skin | Macrophages, Langerhans cells, dendritic cells, mast cells |
| Gut & Intestinal Peyer’s Patches | Macrophages |
| Lungs | Macrophages, monocytes, mast cells, dendritic cells |
| Blood | Neutrophils, monocytes |
| Bone Marrow | Macrophages, monocytes, sinusoidal cells, lining cells |
| Connective Tissue | Macrophages, monocytes, dendritic cells, histiocytes |
| Lymphoid Tissue | Macrophages, monocytes, dendritic cells |
| Spleen | Macrophages, monocytes, sinusoidal cells |
| Thymus | Macrophages, monocytes |
These regions play a crucial role in immune surveillance and are also the most effective sites for MAT-Pure administration:
Skin: via subcutaneous (SC) or intramuscular (IM) injection
Gut: via oral administration
Lungs: via inhalation using a nebulizer
By targeting these macrophage-rich areas, MAT-Pure ensures efficient absorption and activation, maximizing immune modulation and therapeutic results.
MAT-Pure is a Gc protein–derived macrophage activating factor (GcMAF) — a natural glycoprotein that restores the immune system’s ability to defend and repair the body.
It works by activating macrophages, the immune system’s “front-line soldiers,” and boosting their ability to identify, target, and eliminate harmful cells and pathogens. Once activated, these macrophages can also stimulate and transform into Natural Killer (NK) cells, which play a vital role in destroying cancer cells and infected tissues.
Through this process, MAT-Pure helps the immune system regain balance, improve cellular communication, and enhance the body’s natural healing response.
MAT-Pure represents the next generation of GcMAF-based immunotherapy — designed for maximum purity, stability, and effectiveness.
Best in Class
Developed with a patented IMMI24 process for superior bioactivity and stability, setting a new standard in macrophage activation therapy.
Slow Release Over 7 Days
Provides sustained immune activation, ensuring continuous macrophage and NK cell stimulation throughout the week.
Activates Endogenous GcMAF
Boosts the body’s own natural production of GcMAF, enhancing long-term immune resilience.
No Side Effects
Clinically shown to be well tolerated and free of toxicity in the vast majority of patients.
Contains No Human Materials
100% synthetic and biocompatible formulation, ensuring purity, safety, and ethical manufacturing standards.
MAT-Pure is produced using a patent-pending manufacturing process developed by IMMI24 in collaboration with leading immunotherapy specialists, including Dr. M.C., in Singapore and Switzerland.
This advanced process yields a high-purity, highly active Gc protein–derived macrophage activating factor (GcMAF) with exceptional stability and bioavailability.
By combining precision biotechnology with medical expertise, MAT-Pure represents a new generation of immune activation therapy — scientifically engineered to support immune repair, enhance macrophage function, and promote long-term cellular health.
MAT-Pure represents a major advancement in GcMAF-based immunotherapy — created through a new, patent-pending production process developed by IMMI24.
Compared to earlier GcMAF products, MAT-Pure offers:
Higher Concentration:
The formulation is significantly more potent, providing a stronger macrophage activation effect per dose.
Enhanced Bioactivity:
Its improved molecular structure ensures superior immune response and longer-lasting activation of macrophages and NK cells.
Exceptional Stability:
Resistant to oxidation, MAT-Pure maintains full potency over time — ensuring consistent performance even during storage and global shipping.
No Human-Derived Substances:
100% synthetic and biocompatible, making it safe, clean, and compliant with modern ethical standards.
Clinically Proven Safety:
Studies and clinical use show no significant side effects in the vast majority of patients.
In short, MAT-Pure is more concentrated, more stable, and more active — setting a new benchmark in next-generation immune activation therapy.
MAT-Pure has been scientifically tested for long-term stability and preserves full macrophage activation activity for at least two years at room temperature.
Extended stability studies conducted by IMMI24 confirmed that MAT-Pure remains highly potent after 24 months with no measurable loss of biological activity.
Its advanced formulation and oxidation-resistant design ensure that MAT-Pure retains purity, strength, and effectiveness even during worldwide storage and shipping.
In addition to MAT-Pure, IMMI24 develops and produces a range of advanced immunotherapies designed to strengthen and restore the body’s natural defense systems.
Our portfolio includes:
Therapeutic Peptides – Specialized bioactive peptides that support immune modulation, cellular repair, and metabolic balance.
Mito-Organella Therapy – Targeted mitochondrial formulations developed to enhance cellular energy, detoxification, and immune resilience.
Nano Detoxification Systems – Innovative nanotechnology-based detox solutions that help eliminate toxins and heavy metals, improving overall cellular function.
IMMI24 continuously collaborates with international research institutions, medical centers, and clinics worldwide to develop new and more effective immunotherapies for patients seeking natural and science-backed healing solutions.
MAT-Pure macrophage activation therapy is indicated for conditions where the immune system is weakened, imbalanced, or dysregulated. By restoring macrophage function and reactivating natural immune responses, MAT-Pure supports the body in managing a wide range of chronic, viral, and autoimmune diseases.
| Category | Examples |
|---|---|
| Cancer & Oncology | Various types of cancer, leukemia, and tumor-related immune suppression |
| Viral Infections | HIV/AIDS, Hepatitis B (HBV), Hepatitis C (HCV), Epstein–Barr Virus (EBV), Herpes Simplex Virus (HSV), Human Papillomavirus (HPV), Influenza, Chickenpox (Varicella Zoster), Norovirus, Dengue fever, Q fever (Coxiella burnetii) |
| Autoimmune & Inflammatory Disorders | Lupus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), Psoriasis, Ulcerative Colitis, Crohn’s Disease, Type 1 Diabetes (T1DM), Latent Autoimmune Diabetes (LADA), Endometriosis |
| Neurological & Chronic Conditions | Autism Spectrum Disorders (ASD), Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME), Fibromyalgia, Parkinson’s Disease |
| Bacterial & Parasitic Infections | Tuberculosis, Lyme Disease (Borreliosis), Mycobacteria Infections, Malaria, Pneumonia, Respiratory Tract Infections |
| Immune Deficiency Disorders | Selective IgA Deficiency, Type 1.5 Diabetes, Polycystic Ovary Syndrome (PCOS) |
| Other Conditions | Cystitis, Urinary Tract Infections (UTI), Warts, and general immune dysfunction |
MAT-Pure provides support wherever immune repair and macrophage activation are key to recovery. It works by re-establishing the immune system’s ability to identify and neutralize pathogens, damaged cells, and chronic infections.
MAT-Pure therapy is designed to be personalized and adaptive, depending on the condition being treated and the patient’s immune response. All treatment plans should be supervised by a qualified healthcare provider experienced in immunotherapy.
For patients undergoing integrative cancer therapy, the recommended dosage is:
2 ml High-Dose MAT-Pure (1 vial) per week
Duration: 10–20 weeks, depending on progress and clinical response
This protocol is often combined with other integrative or supportive therapies to enhance overall immune activation and cellular recovery.
For conditions such as Autism Spectrum Disorders (ASD), Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME), and Lyme Disease, the typical recommendation is:
2 ml High-Dose MAT-Pure (1 vial) administered once per week
Duration: variable, depending on individual response and clinical improvement
Each case is unique — dosage duration and intensity may be adjusted by your physician based on your immune profile, treatment goals, and tolerance.
We offer customized therapy plans tailored to your specific health condition and immune status.
➡️ Contact us to receive a personalized MAT-Pure treatment protocol designed for your needs.
MAT-Pure is administered under medical supervision by subcutaneous (SC) or intravenous (IV) injection, typically once per week, or as prescribed by the treating physician.
For optimal safety and precision, the recommended equipment includes:
Needle size: 26G x ½″ (0.45 x 13 mm) or 27G
Syringe size: 2.0 ml or 2.5 ml (sterile, single-use disposable)
The 2.5 ml syringe is often preferred due to its shorter plunger stroke, allowing smoother administration. In some cases, diabetes needles may also be used, as they are finer and suitable for subcutaneous injections.
The most common method for most patients. Injection is performed just beneath the skin, allowing gradual absorption and sustained immune activation over several days.
MAT-Pure may also be administered by:
IV infusion (drip): 2 ml MAT-Pure mixed with 20 ml or more of saline solution.
Push IV: The same volume (2 ml MAT-Pure + 20 ml saline) is injected slowly over approximately 3 minutes using a 20–30 ml syringe.
This method delivers a rapid systemic immune response, particularly beneficial in advanced conditions or integrative oncology settings.
Another effective option is the inhalation method, which delivers MAT-Pure directly to the lungs’ bronchus-associated lymphoid tissue (BALT) — an area rich in immune cells.
For this method, a portable medical nebulizer, such as the Omron NE-U22, can be used.
This approach is particularly well suited for:
Respiratory conditions
Lung infections
Pulmonary immune support
Local administration in the lungs can provide a stronger localized immune response where it’s most needed.
| Method | Frequency | Typical Use Case |
|---|---|---|
| Subcutaneous (SC) | Once weekly | Most common, gradual systemic effect |
| Intravenous (IV) | Once weekly | Advanced cases, rapid immune activation |
| Nebulizer (Inhalation) | As prescribed | Lung and respiratory conditions |
A standard MAT-Pure treatment course typically consists of 10 doses over 10 weeks (one injection per week). However, the duration of therapy can vary depending on several factors, including the type and stage of disease, symptom progression, and overall immune response.
Initial Course:
1 vial (2 ml High-Dose MAT-Pure) administered once weekly for 10 weeks.
Extended Therapy:
Additional treatment cycles may be recommended based on individual progress and medical evaluation. Chronic or advanced conditions often benefit from longer treatment periods to achieve stable immune restoration.
Maintenance Phase:
After improvement or remission, long-term maintenance dosing may be advised — typically once per week — to help prevent recurrence and support ongoing immune balance.
Consistent macrophage activation is essential for maintaining a healthy, resilient immune system.
Therefore, MAT-Pure therapy should continue:
As long as the disease is present, and
For a period afterward to reduce the risk of relapse and promote sustained wellness.
By keeping the immune system active and responsive, MAT-Pure helps the body remain strong, balanced, and disease-free.
Regular medical monitoring during MAT-Pure therapy helps track progress, measure immune response, and ensure the treatment is achieving optimal results.
For individuals undergoing MAT-Pure therapy as part of an integrative cancer treatment, we recommend:
Regular evaluation of tumor markers
Periodic MRI, PET, or CT scans to assess treatment response and tumor reduction
These imaging and biomarker tests provide an objective measure of how the immune system and therapy are working together to target abnormal cells.
A key indicator of immune activation during MAT-Pure therapy is the monocyte count — a blood parameter reflecting macrophage precursor activity.
During the early stages of treatment, an increase in monocyte count and percentage is expected.
This rise indicates that MAT-Pure is successfully activating macrophages, triggering a healthy immune response.
Example: In patients with advanced cancer (e.g., Stage 4 breast cancer), consistent weekly administration of 2 ml MAT-Pure via intramuscular injection has been shown to elevate monocyte levels, corresponding to improved immune function and recovery progression.
Monocyte percentage and total count (weekly or biweekly)
Tumor markers (as applicable)
Imaging scans (MRI, PET, CT) for disease monitoring
Vitamin D and calcium levels (to ensure optimal macrophage activation)
Tracking these markers provides valuable feedback on immune status and helps clinicians tailor ongoing therapy for maximum benefit.
MAT-Pure has been clinically demonstrated to be free of significant side effects in the vast majority of patients.
Its advanced formulation and high purity make it one of the safest forms of macrophage activation therapy available today.
In rare cases — approximately 1 in 10,000 patients — mild, short-term reactions have been observed, such as:
Low-grade fever
Temporary skin irritation or eczema
These effects are generally brief and far less frequent than those reported with most other immunotherapies.
A small number of patients may also experience mild local skin reactions at the injection site. These can be easily managed with a non-steroidal anti-inflammatory patch or topical treatment.
Overall, MAT-Pure is well tolerated, non-toxic, and suitable for long-term immune support in both preventive and therapeutic settings.
Yes. MAT-Pure can be safely integrated with a wide range of standard medical treatments and pharmaceutical therapies to enhance their effectiveness — an approach known as multimodality integrative medicine.
MAT-Pure works synergistically with most cancer treatments:
Chemotherapy:
While chemotherapy may temporarily suppress immune function, combining it with MAT-Pure can help boost overall immune recovery and enhance the treatment’s tumor-killing effects.
For best results, MAT-Pure should be administered a few days apart from chemotherapy sessions.
Radiation Therapy (Radiotherapy):
Radiation has less impact on immune activity and can actually support macrophage targeting of tumor cells.
MAT-Pure can therefore be used concurrently with radiation without loss of efficacy.
Anti-Cancer Medications & Targeted Therapies:
MAT-Pure complements hormone therapies, monoclonal antibodies, angiogenesis inhibitors, and signal transduction inhibitors, promoting a more complete immune response.
In clinical practice, significant tumor regression and immune activation have been observed in patients treated with MAT-Pure in combination with palliative radiotherapy, even after extensive prior chemotherapy.
This demonstrates MAT-Pure’s role as a powerful adjunct — not a replacement — in comprehensive cancer care strategies.
Yes. For optimal effectiveness, MAT-Pure therapy should be combined with Vitamin D3 supplementation, as vitamin D plays a critical role in the macrophage activation process.
Vitamin D3:
A daily intake of 5,000 – 20,000 IU is typically recommended during MAT-Pure therapy.
Many patients with chronic diseases — including cancer, HIV/AIDS, and autoimmune conditions — have low vitamin D levels, which can reduce immune activity and limit the response to MAT-Pure.
It is essential to monitor the following through regular blood tests:
25-hydroxy vitamin D (25(OH)D)
Calcium levels
Maintaining normal vitamin D levels ensures that MAT-Pure functions at full immune-activating capacity.
If calcium levels rise above normal, the vitamin D3 dose may need to be reduced to maintain healthy balance and avoid over-supplementation.
MAT-Pure is compatible with most standard medications and therapies, making it highly adaptable for use in integrative treatment plans.
However, certain substances can suppress immune activity and should be minimized whenever possible — particularly steroids.
Steroids (such as cortisone or prednisolone) can temporarily suppress macrophage activity, reducing the immune-activating effects of MAT-Pure.
If steroid treatment is medically necessary, it can still be used safely under a doctor’s supervision, with careful dosage and timing adjustments.
By minimizing immunosuppressive drugs and maintaining healthy vitamin D levels, you help maximize the effectiveness of MAT-Pure therapy.
Nagalase testing is not required for beginning or continuing MAT-Pure therapy.
This is because macrophage activation — the core mechanism of MAT-Pure — is essential for effective immune function in all individuals, regardless of Nagalase levels.
MAT-Pure supports the immune system’s ability to identify and destroy cancer cells, bacteria, and viruses, making ongoing activation beneficial whenever the body is fighting disease.
However, for cancer patients, we recommend optional Nagalase testing as a useful biomarker for monitoring immune and metabolic activity.
This can help track progress and evaluate changes in disease status during therapy.
➡️ Contact us if you’d like assistance arranging a Nagalase test or interpreting your results.