MAT-Pure (Macrophage Activating Therapy based on Gc Protein) is a next-generation formulation derived from the original GcMAF protein. Naturally present in the human body, it activates macrophages — the key immune cells responsible for detecting and destroying harmful invaders such as cancer cells, bacteria, and viruses.
Chronic conditions like cancer, HIV, and viral hepatitis are often associated with a weakened macrophage response. MAT-Pure reawakens this vital defense mechanism, helping the immune system restore its natural ability to protect and regenerate the body.
Produced in a specialized sterile laboratory, MAT-Pure delivers a high-purity, bioactive formulation administered intravenously (IV) or subcutaneously (SC) — typically once, and in some cases twice, per week. Over several weeks and months, it enhances immune performance, empowering the body to target and eliminate cancer cells, viruses, and pathogens.
The MAT-Pure immune activation program is designed to restore natural defense mechanisms and support overall vitality. Its key goals are to:
Activating macrophages with high-dose MAT-Pure is a powerful component of any comprehensive treatment program. It can be used alone or in combination with other therapies, enhancing overall effectiveness without suppressing the immune system.
MAT-Pure works particularly well in synergy with targeted therapies that preserve immune integrity — including hormone therapies, monoclonal antibodies, small-molecule drugs, signal transduction inhibitors (such as HER2, BRAF, and EGFR inhibitors), angiogenesis inhibitors, and modern immunotherapy agents like CTLA-4 inhibitors.
Unlike many conventional treatments, MAT-Pure has no known side effects and can be safely continued for as long as the disease is present. This makes it a sustainable and non-toxic option compared to therapies with cumulative toxicity that limit long-term use.
MAT-Pure never loses its effectiveness — it continues to activate macrophages and support immune function throughout the course of therapy.
MAT-Pure is produced using a patented process developed by IMMI24, designed to deliver a highly concentrated, bioactive, and stable formulation of the original GcMAF protein. Manufactured in our sterile cell facility, MAT-Pure represents the next generation of macrophage-activating therapy — more potent, more stable, and better tolerated than previous versions of GcMAF.
Clinical experience has shown that this high-concentration MAT-Pure is largely free of side effects in the vast majority of patients. Its enhanced resistance to oxidation ensures greater stability and reliability during treatment.
Each 3.0 ml vial of High-Dose MAT-Pure contains approximately 7,000 ng of GcMAF-equivalent activity.
100% natural immunotherapy product
Produced under sterile laboratory conditions
Safely used in hundreds of patients in our partner clinics
Administered via intravenous (IV) or subcutaneous (SC) injection
Macrophages (from the Greek “big eaters”) are powerful immune cells derived from monocytes, a type of white blood cell. They play a vital role in both innate (non-specific) and adaptive (targeted) immunity.
Their function is to engulf and digest pathogens, cancer cells, and cellular debris — essentially “cleaning up” the body. Macrophages also stimulate lymphocytes and other immune cells, acting as a central command unit that coordinates the body’s defense system.
These specialized cells are essential for protecting against foreign substances, infections, and tumor growth — and are the main target of activation by MAT-Pure therapy.
Vitamin D-Binding Protein (DBP), also known as Gc Protein, is naturally produced in the liver and plays a central role in transporting and storing Vitamin D in the body. When modified through glycosylation (GaINAc-modified), this protein becomes the Macrophage Activating Factor (MAF) — the foundation of MAT-Pure’s biological mechanism.
DBP also acts as a key scavenger of extracellular G-actin, crucial for liver health and cellular protection. While it helps activate macrophages, it does not interfere with Vitamin D absorption or function, ensuring safety even at elevated levels
Vitamin DBP levels can fluctuate based on health status:
Liver disease (especially acute liver failure) lowers production.
Trauma and surgery temporarily reduce DBP levels.
Septic infections accelerate DBP consumption faster than the body can replace it.
Normal serum concentrations range between 350–500 mg/l.
Levels below 80 mg/l correlate with poorer outcomes.
Levels above 100 mg/l are typically associated with improved recovery and survival.
Macrophage Activation Factors (MAF) are glycoproteins that enhance macrophage activity and can stimulate their transformation into Natural Killer (NK) cells.
The glycosylated form of Gc Protein (Vitamin DBP) is the most potent MAF — and the scientific basis of MAT-Pure. By reactivating this natural immune pathway, MAT-Pure helps the body restore its defense and repair functions at a cellular level.
If you wish to begin MAT-Pure therapy, please contact us via email with the following details:
Your current medical condition and diagnosis
Any ongoing treatments or medications
The quantity of MAT-Pure vials you would like to order
After receiving your information, we will provide complete details regarding pricing, payment, and delivery
High-Dose MAT-Pure 3.0 ml vial (7,000 ng/3 ml): €390
Therapy Pack – 10 vials x 3.0 ml (7,000 ng/3 ml each): €3,900
Each vial of MAT-Pure contains a highly concentrated GcMAF-based formula for immune activation and macrophage support
MAT-Pure is formulated for worldwide shipping and maintains its full bioactivity during transport. Laboratory testing confirms maximum potency for up to two years of storage under recommended conditions.
Store in a cool, dry place
Avoid direct sunlight and high temperatures